Awards – Awards

Dr. Antony K. Chen receives Bayer Investigator Award 2023

CHENLAB Congratulations! Read More ›

publication – Article-HIV Assembly

Roles of RNA scaffolding in nanoscale Gag multimerization and selective protein sorting at HIV membranes

CHENLAB Through systematic comparisons of the nanoscale organizations and dynamics of Gag expressed in the presence or the absence of gRNA (so that cellular RNAs become predominantly packaged), we provide evidence that Gag progresses through quite distinct pathways to multimerize around gRNA or cellular RNAs. We also demonstrated that the two processes may lead to different transmembrane protein compositions in HIV membranes. Read More ›

Awards – Awards

Dr. Jinshan Qin receives 2023 Boehringer Ingelheim Postdoc Fellowship Award

CHENLAB Congratulations! Read More ›

publication – Article-RNA nanostructure

Rational design of self-assembled RNA nanostructures for HIV-1 virus assembly blockade

CHENLAB Here, we develop self-assembled RNA nanostructures that can inhibit HIV-1 virus assembly, achieved through hybridization of multiple artificial small RNAs with a stem–loop structure (STL) that we identify as a prominent ligand of Gag that can inhibit virus particle production via STL-Gag interactions. Read More ›

publication – Article-Bimolecular Fluorescence Complementation

A Background Assessable and Correctable Bimolecular Fluorescence Complementation System for Nanoscopic Single-Molecule Imaging of Intracellular Protein–Protein Interactions

CHENLAB We have developed Background Assessable and Correctable-BiFC (BAC-BiFC) that enables physiologically relevant characterization of specific PPIs at the nanoscopic level not attainable by conventional BiFC. Read More ›